Q Exactive

The Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometer combines high-performance quadrupole precursor selection with high-resolution, accurate-mass (HR/AM) Orbitrap™ detection.

The superior quality of Q Exactive™ MS/MS data provides ultimate confidence for a wide range of qualitative and quantitative applications. Its high scan speed and spectral multiplexing capabilities make it fully compatible with UHPLC and fast chromatography techniques, ramping productivity to a new level. The Q Exactive instrument can easily handle routine applications in proteomics from bottom-up protein ID to semiquantitative isotopic labeling analyses to targeted quantification experiments. At the same time, its innovative HR/AM Quanfirmation™ capability makes the Q Exactive mass spectrometer the ideal solution for fast, easy residue screening and quantification in food safety, environmental and toxicology labs.

The Q Exactive MS is superbly suited to routine bioanalytical quantitation of both large and small molecules; the superior quality of its HR/AM data supplying an added degree of confidence to these analyses. It is also ideal for pharmaceutical research laboratories looking for confident ID and precise quantification of metabolites, impurities, leachables and extractables. In short, the versatility and high data quality of the Q Exactive LC-MS/MS system make it a valuable addition to any modern laboratory.

Related Publications

Michalski A, Damoc E, Hauschild JP, Lange O, Wieghaus A, Makarov A, Nagaraj N, Cox J, Mann M, Horning S “Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer.” Mol Cell Proteomics, 2011, 10(9) p. M111.011015.

Summary | Full Text (PMC) | Full Text (DOI)

Nagaraj N, Kulak NA, Cox J, Neuhauser N, Mayr K, Hoerning O, Vorm O, Mann M “System-wide perturbation analysis with nearly complete coverage of the yeast proteome by single-shot ultra HPLC runs on a bench top Orbitrap.” Mol Cell Proteomics, 2012, 11(3) p. M111.013722.

Summary | Full Text (PMC) | Full Text (DOI)

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