Untargeted Metabolomics

We have used mass spectrometry-based proteomics to detect bacterial and fungal secondary metabolites as well as their intermediates.

Related Publications

Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW “Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection.” ACS Chem Biol, 2013, 8(5) p. 908-13.

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Shaw JB, Li W, Holden DD, Zhang Y, Griep-Raming J, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS “Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation.” J Am Chem Soc, 2013, 135(34) p. 12646-51.

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Albright JC, Goering AW, Doroghazi JR, Metcalf WW, Kelleher NL “Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways.” J Ind Microbiol Biotechnol, 2014, 41(2) p. 451-9.

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Instruments Used

Q Exactive