On June 29, 2021, Neil L. Kelleher, PhD, director of Northwestern Proteomics and Chemistry of Life Processes Institute, gave a Zoom presentation, entitled “Case Studies of Proteoforms in Human Health and Disease” at a biannual Translational Applications in Medical Research Lecture event sponsored by at the NUCATS Institute and Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

In humans, proteins that arise from single genes have diverse sources of possible variation, including alternative RNA splicing and post-translational modification, which create many different molecular forms. “Proteoform” is the term used for distinct protein molecules that incorporate such variations (including genetic mutation). There are many examples of proteoforms that are measured in clinical practice. Northwestern Proteomics, led by Neil Kelleher, PhD, is systematically mapping the proteoforms of key proteins in four main disease areas. Through a Northwestern Proteomics Initiative (NPI), it seeks expanded engagement for translational research leveraging a leading position in the science and technology of proteoform measurement from clinical specimens. During this lecture, examples in cardiology (ApoA-I) and immunology (IgG repertoire recognizing SARS-CoV-2) will be described, along with future collaborative opportunities via the NPI.

Watch the video of Professor Kelleher’s presentation below.