Setting audacious goals for technology innovation is a critical component of the Human Proteoform Project, a $1.3 billion movement to weigh and characterize every protein variation, (called proteoforms) in the human body.  A new technology announced today, co-developed by Northwestern’s […]
Proteomics is a broad term that can generically be defined as the study of the proteome, or the landscape of proteins expressed within a given biological context. More specifically, proteomics can entail investigating aspects of the proteome such […]
Northwestern University scientist have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care. The advancement marks the beginning of a new era for […]
Eight years ago, an international team of researchers proposed that the term “proteoform” be adopted to describe the vast number of forms of protein products from our genes—including changes due to genetic variations, alternative RNA splicing, and post-translational […]
This episode of Northwestern University Feinberg School of Medicine’s Breakthroughs Podcast features Neil Kelleher, PhD, director of Northwestern Proteomics and Chemistry of Life Processes Institute. Millions of molecular proteins are swimming through our body’s cells and many studies […]
The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics’ (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed […]
Now that the Human Genome Project has officially wrapped, an international team of researchers will map the entire collection of proteins in the human body. Plans and goals for the Human Proteoform Project were outlined in a paper published last […]
The Human Genome Project (HGP) was a remarkable and unqualified success profoundly transforming and accelerating biological and medical research while converting a ~ $4B public investment into over $700B of economic activity and new industries (1). The challenge of revealing […]
Sugars are found in cells and on the cell surface. The Human Proteoform Project will include mapping glycoproteoforms. Nucleic acids, proteins, lipids and small molecules are major constituents of the human cell but as molecular biology barreled ahead […]
An interview with Prof. Neil Kelleher, conducted by Alina Shrourou, BSc It has been announced that you will be doing a talk as part of the “Structural Mass Spectrometry and Top Down Proteomics of Proteoforms and Their Complexes” […]