Eight years ago, an international team of researchers proposed that the term “proteoform” be adopted to describe the vast number of forms of protein products from our genes—including changes due to genetic variations, alternative RNA splicing, and post-translational […]
Chemistry of Life Processes Institute has selected two high-risk, potentially high-reward biomedical research projects to receive CLP Cornew Innovation Awards. The 2021-22 awards will support the development of new technology for creation of viral nanoparticles for gene therapy and […]
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light […]
This episode of Northwestern University Feinberg School of Medicine’s Breakthroughs Podcast features Neil Kelleher, PhD, director of Northwestern Proteomics and Chemistry of Life Processes Institute. Millions of molecular proteins are swimming through our body’s cells and many studies […]
The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics’ (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed […]
Now that the Human Genome Project has officially wrapped, an international team of researchers will map the entire collection of proteins in the human body. Plans and goals for the Human Proteoform Project were outlined in a paper published last […]
The Human Genome Project (HGP) was a remarkable and unqualified success profoundly transforming and accelerating biological and medical research while converting a ~ $4B public investment into over $700B of economic activity and new industries (1). The challenge of revealing […]
Renowned proteomics expert Neil L. Kelleher has been named director of the Chemistry of Life Processes Institute (CLP), effective Sept. 1. Kelleher succeeds Thomas O’Halloran, who led CLP since it launched in 2005. Kelleher is the Walter and Mary Glass Professor of […]
Sugars are found in cells and on the cell surface. The Human Proteoform Project will include mapping glycoproteoforms. Nucleic acids, proteins, lipids and small molecules are major constituents of the human cell but as molecular biology barreled ahead […]
Participants in a NIH Workshop on Functional and Integrative Proteomics Abstract. All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we […]