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A team approach is essential when developing more effective treatments for ALS (amyotrophic lateral sclerosis), a progressive neurodegenerative disease affecting nerve cells in the brain and spinal cord. In her ongoing effort to determine the role of proteins […]

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Dr. Neil L. Kelleher is the Walter and Mary E. Glass Professor of Molecular Biosciences, Professor of Chemistry in the Weinberg College of Arts and Sciences, and Professor of Medicine (Hematology & Oncology) in the Feinberg School of […]

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The Human Proteoform Project needs a US$1.3 billion moonshot to transform our understanding of protein-based disease Neil Kelleher has previously discussed the many merits of top-down proteomics and how they will enable “the earlier and more precise detection […]

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Congratulations to Jared Kafader, PhD Research Assistant Professor here at Northwestern Proteomics for making The The Analytical Scientist‘s Top 40 Under 40 2022 Power List! A well-deserved honor. Find out who else made the list here – https://bit.ly/3T0jNOB

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In the coming decades, efforts to understand disease will be propelled by building 3D maps of protein arrangements in cells over time, a team of scientists says. A workshop about the study of proteins on a large scale […]

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Investigators led by Neil Kelleher, PhD, professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, have developed a new imaging technique that increases the detection of intact proteoforms by fourfold when compared to current protein imaging methods. The […]
With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. Collectively, these sets are called proteomes, and […]
As new technology enables researchers to find and characterize less-common post-translational modifications that drive gene expression and cellular metabolism, the movement to catalog the entire human proteome gains momentum Sequencing the human genome provided biologists with a potential […]

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In a new article in ACS Chem. Biol., a team of researchers led by Northwestern Proteomics graduate student Luis Schachner show that measuring proteoforms – the specific molecular forms of proteins including post-translational modifications – can shed new […]

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Northwestern Medicine investigators have discovered novel mechanisms that regulate a cell’s response to molecular stressors, according to a study published in the Proceedings of the National Academy of Sciences. The findings may help improve the understanding of how cancer and other […]