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A team approach is essential when developing more effective treatments for ALS (amyotrophic lateral sclerosis), a progressive neurodegenerative disease affecting nerve cells in the brain and spinal cord. In her ongoing effort to determine the role of proteins […]

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Dr. Neil L. Kelleher is the Walter and Mary E. Glass Professor of Molecular Biosciences, Professor of Chemistry in the Weinberg College of Arts and Sciences, and Professor of Medicine (Hematology & Oncology) in the Feinberg School of […]

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The Human Proteoform Project needs a US$1.3 billion moonshot to transform our understanding of protein-based disease Neil Kelleher has previously discussed the many merits of top-down proteomics and how they will enable “the earlier and more precise detection […]

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Congratulations to Jared Kafader, PhD Research Assistant Professor here at Northwestern Proteomics for making The The Analytical Scientist‘s Top 40 Under 40 2022 Power List! A well-deserved honor. Find out who else made the list here – https://bit.ly/3T0jNOB

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In the coming decades, efforts to understand disease will be propelled by building 3D maps of protein arrangements in cells over time, a team of scientists says. A workshop about the study of proteins on a large scale […]

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Investigators led by Neil Kelleher, PhD, professor of Medicine in the Division of Hematology and Oncology and of Biochemistry and Molecular Genetics, have developed a new imaging technique that increases the detection of intact proteoforms by fourfold when compared to current protein imaging methods. The […]
With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. Collectively, these sets are called proteomes, and […]
As new technology enables researchers to find and characterize less-common post-translational modifications that drive gene expression and cellular metabolism, the movement to catalog the entire human proteome gains momentum Sequencing the human genome provided biologists with a potential […]
Chemistry of Life Processes Institute (CLP) director Neil L. Kelleher and members of the CLP and Northwestern Proteomics team welcomed U.S. Congresswoman Jan Schakowsky from the 9th District of Illinois to Silverman Hall today to discuss the promise and potential of the Human Proteoform […]

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Northwestern Medicine investigators have discovered novel mechanisms that regulate a cell’s response to molecular stressors, according to a study published in the Proceedings of the National Academy of Sciences. The findings may help improve the understanding of how cancer and other […]